Major Criteria
- Exposure to an external stimulus (infection, vaccine, silicone, adjuvant) prior to clinical manifestations
- The appearance of ‘typical’ clinical manifestations
- Myalgia, Myositis or muscle weakness
- Arthralgia and/or arthritis
- Chronic fatigue, un-refreshing sleep or sleep disturbances
- Neurological manifestations (especially associated with demyelination)
- Cognitive impairment, memory loss
- Pyrexia, dry mouth
- Removal of inciting agent induces improvement
- Typical biopsy of involved organs
Minor Criteria
- The appearance of autoantibodies or antibodies directed at the suspected adjuvant
- Other clinical manifestations (i.e. irritable bowel syndrome)
- Specific HLA (i.e. HLA DRB1, HLA DQB1)
- Evolvement of an autoimmune disease (i.e. multiple sclerosis, systemic sclerosis)
"Patients are considered to have ASIA when either two major or one major and two minor criteria are present."